Summary

There are a lot of reasons to revisitEnter The Gungeon, the indieroguelike bullet hellfrom Dodgeroll Games. The game has a lot of replayability, even for long-time players, having had significant updates since its 2016 release. There are hundreds of guns and items to unlock, many bosses to fight, secrets to discover, and different modes to run.

One of the most interesting parts ofEnter The Gungeon’s roguelike designis its item synergies. During a run, players will pick up passive and active items as well as weapons. Certain combinations of items, weapons, or items and weapons have specific synergies, which will give the player additional bonuses on top of the item or weapon’s standard effects.

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There are a lot of these synergies, and some of them require multiple items or weapons. This topic will focus on synergies that require two items or an item and a weapon to work, as these are by far the easiest to obtain in a single run. Longer synergy combos require a heavy amount of luck to assemble, even for long-time players. With that in mind, these are the best Synergies inEnter The Gungeon.

10Old Goldie + Gilded Bullets

Low Health, High Damage

The shotgun Old Goldie and the passive item Gilded Bullets make a powerful combo, as the weapon gains 25% increased damage while the bullets are held. This becomes even more powerful due to the weapons' hidden properties though.

As the player loses hearts, the weapon gets even more damage. At its maximum bonus plus the bullets' effect, the shotgun does around 220 damage with its 10 pellets, making it great forclearing out rooms fast.

Enter the Gungeon king bullet

9Lil' Bomber + Coin Crown

Golden Bombs

King Bomber is a great combo for players who want to amass a lot of currency in a run. It’s also very obtainable, with both pieces often found withinthe early parts of a player’s run. That’s partly because there are a few different combos that can activate this effect.

The Lil' Bomber weapon is always required, but the bonus will activate with the Gilded Bullets and the Crown of Guns, as well as the Coin Crown.

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8Metronome + Drum Clip

Combat Rhythm

For players who are confident in theirEnter The Gungeonskills, there are few synergies as effective as Keeping the Beat. Themetronome itemgives players a stacking damage bonus until they get hit or change guns, and the drum clip doubles the bonus and increases its maximum cap. At a 75-kill streak, players will deal 250% increased damage. That’s only if they can avoid all hits, though.

7Chest Teleporter + Teleporter Prototype

Potent Prototype

This item combo almost feels like cheating.The teleporter itemis great for players who want to gamble on moving swiftly through theGungeon. It can cause problems if players teleport into the middle of a tough group of enemies, though.

This combo solves that issue, as it will instantly kill enemies if players teleport into a combat room. The teleporter also gains a shorter cooldown if players land in a secret room with this synergy.

Enter The Gungeon Secret room

6Gunsoul + Old Knight’s Flask

Somewhat Souls-Like

Everyone loves aDark Soulsreference in theirindie roguelike. This one comes with a significant practical benefit, too. When the player has both the Gunsoul and the Old Knight’s Flask items, bonfires will appear at shops and elevators, and the player can respawn at these instead of the start of a floor. As an added bonus, dodge roll cooldowns are also shortened.

5Gunknight Greaves + Ballistic Boots

Revenge Time

For players who want a bit of breathing room when they take a hit, the Knight Time synergy is a strong combo. With both the Gunknight Greaves and Ballistic Boots held, players will stop time when hit. The time stop effect is brief, but it gives the player a few moments to reposition or finish off troublesome enemies.

4Lowercase r + Explosive Rounds

Uppercase R

The Lowercase r has more different synergies than any other weapon. With the explosive rounds equipped, not only do the Lowercase r’s rounds become explosive, they also spell out words like ROCKET and KABOOM when fired. This works with many types of rounds and other items, even some weapons, with each changing the r’s properties and firing pattern.

3Gungeon Ant + Crown Of Guns

Queen Gungeon Ant

Finding the Great Queen Ant synergy for the Gungeon Ant turns a mediocre weapon into a top-tier clearing machine. There are a few ways to activate this synergy; if the Crown of Guns or Heck Blaster weapons are acquired alongside the Gungeon Ant, or if the player gets the Ring of Fire Resistance, Gilded Bullets, or the Coin Crown items. Any one of these turns the Ant into the Ant Queen, which then fires explosive rocket ants for more damage.

2AKEY-47 + Shelleton Key

Trade Utility For Damage

This synergy removes the ability of the AKEY-47 to function as a key, but it grants a big damage boost and infinite ammo in return. This buff almost doubles the per-shot damage of the weapon (plus 10 per shot), and infinite ammo is one of the strongest abilities for any weapon to possess. This turns the AKEY-47 from a solid weapon with amazing utility, into a run-winning gun forsolo or co-op.

1Betrayer’s Shield + Lies

Infinite Damage

In terms of helping players to easily clear rooms and defeat bosses, the synergy between the Betrayer’s Shield weapon and the Lies passive item might be the strongest in the game.

With Lies held, the Betrayer’s Shield gains infinite ammo, bigger clips, and a much higher fire rate that can spit bullets at ridiculous speed. With the guns' innate ability to place a shield that blocks enemy bullets when reloading, this becomes one of the strongest weapons in the game with this synergy.

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